Shadow Harvest is set in the year 2025. The player takes control over two ISA agents (Myra Lee and Aron Alvarez) which are are deployed as elite black-ops agents on various current and future points of conflict around the globe to cooperatively complete covert operations. Both characters are very different from each other and also have very different special skills. To optimally achieve all mission goals, the player needs to combine Myra's stealth skills, cleverness and athletic abilities with Aron's blunt open battle approach.

The dual-character storyline of Shadow Harvest makes for a unique blend of action and strategy. Besides being a fast-paced tactical action game when playing with Aron, Shadow Harvest also features real stealth and action-adventure elements when playing with Myra. Its refreshingly new mix of features allows new possibilities in interactive storytelling and lets the player dive deep into a thrilling storyline in an immersive and unique gaming experience.