Pokémon Black Version and Pokémon White Version feature new Pokémon that players can catch, train and battle as they progress through the game, and some Pokémon can only be caught in one version of the game. For example, the Legendary Pokémon Reshiram can only be caught in Pokémon Black Version, while the Legendary Pokémon Zekrom can only be caught in Pokémon White Version. Additionally, the two games feature different areas for the first time in the series, with the game world of Pokémon Black Version featuring a unique metropolitan area called Black City, and a lush, green area named White Forest only found in Pokémon White Version. Pokémon Black Version and Pokémon White Version also mark the first time in a Pokémon video game that the seasons will change in the game world. Certain Pokémon appear more frequently during different seasons, and players can only access some areas during a specific season.

Pokémon Black Version and Pokémon White Version let players start with one of three new Starter Pokémon – the Grass-type Snivy, the Fire-type Tepig or the Water-type Oshawott. Until the main story of the game is complete, every Pokémon that players encounter will have never been seen before in previous Pokémon games. The games also feature original boy and girl trainers who set out on an adventure in the new Unova region.