Each set of platforms will have unique gameplay:

Xbox 360 and PlayStation 3: In this two-player cooperative action-adventure game, a sudden crime wave has hit the city, calling Megamind into action. As Megamind, players must defend the city after his untested and unstable inventions are stolen by a group of new enemies called "The Doom Syndicate". To defeat these vile villains, players will have to operate a variety of Mega-Gadgets, including Tesla Gloves, the Battlesuit and Sticky Boots, as well as build ingenious inventions such as the Mega Essence Tracker and the Bio Essence Neutralizer. The gamealso offers six side mission mini-games and cooperative play with one of Megamind's trusty Brainbots.

Wii: In this classic brawler game, players can choose from up to nine characters from the film and beyond to form a four-player "Mega Squad". The extensive multiplayer campaign includes Competitive, Cooperative and team-based gameplay modes. In addition, artificial intelligence (AI) players can be used to keep the four-player action challenging and fun!

Nintendo DS and PSP: In this on-the-go mega-adventure game, players set out as Megamind, using an arsenal of blasters to smash and blast their way through enemies. Players can switch blasters on a whim in order to put an end to the city's crime wave.